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[Technology and Achievements] Scale-Up Simulation Technology

Introducing examples of techniques such as reaction, concentration, and crystallization! Developing methods to obtain high-quality raw materials reliably in a short time.

By utilizing chemical engineering "scale-up simulation technology" based on accumulated experience, we can proactively resolve issues that arise during scale-up and improve the robustness and productivity of manufacturing. For example, regarding the crystallization method of a raw material that is prone to oiling down and has significant variation in crystal particle size distribution, we developed a reproducible crystallization method using this technology. Additionally, for hydrated raw materials, we thoroughly examined vacuum drying conditions and developed a method to reliably obtain high-quality raw materials in a short time even at commercial scale. 【Examples of Simulation Technology (Partial)】 ■ Concentration - Simulation of solvent composition during single distillation of mixed solvents using proprietary software - Prediction of concentration time - Proposal of suitable concentration methods ■ Crystallization - Scale-up considering stirring power and changes in supersaturation over time - Development of operational methods to reproducibly obtain desired crystal forms and particle sizes - Connecting to LCM through the development of raw materials as cocrystals or suitable salts *For more details, please refer to the PDF document or feel free to contact us.

• Company：スペラファーマ
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